Curator Dashboard

An organization that specifically operates in Kansas and the the western half of Missouri, and provides help with connecting the community to organ and tissue procurement, as well as generates general public awareness. This organization is a federally certified non-profit Organ Procurement Organization (OPO) that is meant to help in several facets of transplant and procurement services.

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• SciCrunch
• 15 years ago - by Anonymous

A lightweight, high-performance graphical viewer for next generation sequence assemblies and alignments.

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• SciCrunch
• 12 years ago - by Anonymous

A software application that maps transcription factor binding sites from ChIP-seq data to high resolution using a blind deconvolution approach.

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• SciCrunch
• 12 years ago - by Anonymous

Software application for viewing and editing sequence trace files.

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• SciCrunch
• 12 years ago - by Anonymous

The Conte Center for the Neuroscience of Mental Disorders (CCNMD) at the University of Pittsburgh offers a highly interactive scientific environment for the study of the neurobiology of schizophrenia. The Center, directed by David A. Lewis, MD, integrates the laboratory and clinical research activities of investigators from the University of Pittsburgh Schools of Medicine and Arts and Sciences and the adjacent Carnegie Mellon University. Collectively, the CCNMD represents a broad array of expertise spanning molecular, systems, cognitive, computational and clinical neuroscience that provides complementary approaches to testing one central hypothesis about the disease process of schizophrenia: A distinctive pattern of molecular alterations in subpopulations of GABA neurons (pathology) creates disturbances in cortical network oscillations (pathophysiology) that underlie the information processing deficits (clinical syndrome) of schizophrenia. The Center's hypothesis is based on widely-replicated data showing reduced expression of the gene that synthesizes the neurotransmitter GABA in the cerebral cortex of individuals with schizophrenia. CCNMD investigators are working to understand how the resulting reduced levels of GABA could lead to impaired synchronization of other networks of neurons in the cerebral cortex specifically, the neuronal networks which subserve cognitive functions that are disturbed in schizophrenia. The CCNMD is composed of 5 research projects that are designed to provide convergent tests of this hypothesis. The synergism of these projects facilitates a translational approach to schizophrenia research, making laboratory findings readily relevant to clinical treatment. The CCNMD's work is directed at identifying pathophysiology-based molecular targets for new therapeutic interventions and at developing biomarkers of this pathophysiology that can be used to monitor the efficacy of such interventions. Thus, the CCNMD is a multi-disciplinary effort directed at testing a mechanistic hypothesis in order to improve our understanding of a core component of the disease process of schizophrenia. In addition, the Conte Center represents a rich environment for training and career development in which individuals can become involved in studies that bring the methods and knowledge of basic neuroscience to address critical questions in clinical schizophrenia research, The CCNMD hopes to help propel the development of new and more effective treatments for individuals with schizophrenia and to provide a vehicle for disseminating the knowledge gained from translational studies of schizophrenia to the broader scientific and lay communities. The Post-Doctoral Training Program in Schizophrenia Research provides extensive training in cutting-edge basic and clinical research strategies for schizophrenia. The National Institute of Mental Health Conte Center for the Neuroscience of Mental Disorders (CCNMD) Undergraduate Research Fellowship provides highly talented undergraduate students with early-career, hands-on engagement in cutting edge neuroscience research. Research opportunities focus on schizophrenia and related disorders and are primarily translational in approach; that is, the CCNMD research approach begins with clinical observations about the disease process that are converted into hypotheses that can be tested in the more tractable conditions of the laboratory in order to guide the development of novel therapeutic interventions.

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• SciCrunch
• 14 years ago - by Anonymous

A statistics and alignment pipeline software that performs the alignment of bisulfite sequence reads and tabulates read-level methylation measurements.

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• SciCrunch
• 12 years ago - by Anonymous

Offline spike sorting software. This software tool for viewing and classifying action potential waveforms (spikes) previously collected from single electrodes, stereotrodes and tetrodes accepts file types from many data acquisition companies and software programs.

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• SciCrunch
• 11 years ago - by Anonymous

Microscope that enables bright field and fluorescence imaging options.

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• SciCrunch
• 12 years ago - by Anonymous

Annotated index for computational neurobiology, focusing on compartmental modeling and realistic simulations of biological neural systems. Has resources to find modeling software and software for computational morphology, phase plane and spike train analysis, and web based neuroinformatics. Provides links to major laboratories, researchers, conferences, education and funding for theoretical neurobiology.

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• SciCrunch
• 16 years ago - by Anonymous

Software package that provides netCDF storage based methods and functions for manipulation of flow cytometry data.

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• SciCrunch
• 11 years ago - by Anonymous

A facility that conducts a wide variety of research programs ranging from cell biology to community-based participatory research. Research is conducted through four academic departments including: the Cancer Research Center, the Prevention Research Center, the Public Health Preparedness Center, the Cardiac Quality improvement initiative and the Center for Health Workforce Studies. This facility also hosts research projects and faculty scholarships to aid Master's and Doctoral students in course work, laboratory rotations and internships.

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• SciCrunch
• 13 years ago - by Anonymous

A commercial antibody supplier that provides research materials for projects such as: protein purification, protein analysis, protein estimation assays, DNA purification, plasmid DNA isolation and transformation, protein quantification assays, and coupled assays for methylation. This supplier also provides buffers, reagents, education programs, and training programs.

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• SciCrunch
• 13 years ago - by Anonymous

A young state university located in the southern part of Portugal.

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• SciCrunch
• 12 years ago - submitted by

Neuroshare aims to develop a standard for accessing neurophysiological data from any vendor's acquisition device or software. An API is defined, and vendors and communities are encouraged to provide implementations of a library of functions that can read data files collected with that vendor's instrument or software. The neuroshare.org website is a collaborative, vendor-neutral area dedicated to public domain standards and software for neurophysiology.This website is part of an SBIR program funded by the National Institute for Neural Disorders and Stroke and it is currently being administered by Bionic Technologies, LLC. The goals of the SBIR program are to (Phase I) create open library and format standards for neurophysiological experiment data and (Phase II) create a set of free, open-source software tools for low-level handling and processing of neurophysiological data. Upon completion of Phase I and II, neuroshare.org will be maintained by a yet to be determined consortium of government, academic and industry partners. The SBIR was awarded in the fall of 2001 and Phase I officially began in Dec, 2001. The detailed goals of the program are summarized below:Phase I goals :(1) Establish a working group to develop and define the API library of functions.(2) A vendor-neutral web site to facilitate the development of the standards and software and publish the completed products. This site has been dubbed Neuroshare. The home page can be found at neuroshare.sourceforge.net.(3) An open, standardized API library definition for accessing neurophysiology data files. This will allow developers to produce analysis programs that can access a variety of proprietary data formats through libraries supplied by the data format owners. The manner of support will be completely determined by the research groups and vendors that supply the libraries. The Phase I standard was created by a working group consisting of international members from industry and academia. Draft standards were published for public review and comment on the neuroshare web site and revised by the working group.The grant has been awarded as a fast-track program so that Phase II begins immediately upon completion of the Phase I milestones in June 2002. Phase II will produce :(1) A set of neuroshare-compliant API libraries for existing data formats developed in collaboration with individual equipment vendors and research groups.(2) A utility for analyzing compliant API libraries for integrity and specification conformance, as well as for error checking imported data files.(3) A set of template programs in C that are meant to be used as an example on how to create a Neuroshare API compliant library and how to call it from an application,(4) An open, standardized file format for neurophysiological experiment data. This format will provide research groups and vendors with a file format for exchanging and/or publishing neural data. The format will also be powerful enough for use as a native format for researchers or vendors that wish to support it in data acquisition hardware/software.(5) Import filters that interface neuroshare-compliant API libraries to Visual Basic, MATLAB, and LabVIEW, NeuroExplorer, and Stranger analysis environments.(6) A utility program for quick header information viewing and searching to aid the organization and management of data files in the standard and proprietary formats.(7) A data file editing program for reviewing, editing, annotating, and splicing neural data files through the neuroshare API libraries and/or standard file formats. The suite will be developed in C, optimized for speed, and will run within 32-bit Windows operating systems. The availability of source code will enable eventual ports to Unix/Linux if desired(8) An add-on for the editing program that will allow review and real-time playback of multi-modal data accessible through the API and/or standard file format. These modes will include neurophysiological signals such as spikes, local field potentials and EEG, as well as experimental signals such as kinematics, stimulation, audio, video, and imaging data.(9) C and MATLAB framework programs for detection and classification of extracellular spikes in the standard data files based on classical and user-supplied algorithms.(10) A complete MATLAB application for reading data from the standard format and performing reverse correlation analysis. This program will serve as a tutorial and modifiable template for users performing analysis in MATLAB.(11) A set of export filters for creating neurophysiological data files with the neural simulation environments NEURON, NEOSIM, GENESIS, and NSL.(12) A comprehensive documentation, and help file set for all of the developed applications.Phase II will require two years of development work and software products will be made available as they are completed. As stated above, the Phase II software products will be made available as free, open-source tools. We have not decided on a license model yet, but are currently leaning towards the GNU General Public License. Revisions and bug-fixes will be maintained through the neuroshare.org website. The mission of neuroshare.org is very focused, but the specific goal list of Phase II may evolve somewhat as software is released and user feedback is received. We very interested in public suggestions about how to improve this development effort and web site. Please direct your feedback to commentsneuroshare.org or refer to our contacts page for other addresses.BackgroundThis endeavor grew out of a meeting held at the Society for Neuroscience 2000 Annual Conference in New Orleans (agenda posted here) to discuss the development of standard data formats for neuroscience. From this meeting, it was clear that although everyone supported the idea of better data portability, many vendors present wanted a standardized API (Application Program Interface) library rather than a universal data format. Based on this meeting, we submitted an SBIR application (with letters of support from key attendants of the SFN meeting) to fund the development of a standardized API definition, data format, and a suite of open source data handling and review tools.

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• SciCrunch
• 16 years ago - by Anonymous

A commercial antibody supplier and provider of various services.

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• SciCrunch
• 16 years ago - by Anonymous

A global cancer institute of the Hospital Corporation of America which offers integrated cancer services with access to current therapies.

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• SciCrunch
• 12 years ago - submitted by

The set of ontologies used within the Monarch Initiative. MONARCH members are free to add new imports.

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• SciCrunch
• 13 years ago - by Anonymous

A commercial antibody supplier and knockout mice producer.

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• SciCrunch
• 13 years ago - by Anonymous